A Hemodynamic Echocardiographic Approach to Disease Severity and Prognosis in Transthyretin Amyloid Cardiomyopathy

doi:10.1016/j.jacadv.2026.103244

Heart failure & cardiomyopathies

A Hemodynamic Echocardiographic Approach to Disease Severity and Prognosis in Transthyretin Amyloid Cardiomyopathy

JACC AdvPublished 22 Sep 2026noninvasive hemodynamic echocardiographic approach to stratify patients with ATTR-CM

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Authors' conclusion

The noninvasive hemodynamic approach provides an alternative and promising method to stratify the risk of clinical outcome in patients with ATTR-CM, potentially improving management strategies.

Study context

Population: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM)patients with ATTR-CM · group 1 115 · group 2 129 · group 3 49
Participants: 293 patients

Comparison: Hemodynamic staging groups based on stroke volume index (SVi) and systolic pulmonary artery pressure (sPAP); cutoffs 30 mL/m² for SVi and 40 mm Hg for sPAP
group 1n = 115reference
group 2n = 129
group 3n = 49
Outcome: Composite of:
All-cause mortality
Heart failure hospitalization

Main finding

As reported in the abstract

Composite of:

All-cause mortality
Heart failure hospitalization

Multivariable Cox regression adjusted for age, sex, and disease-modifying therapy; P printed for the staging system

Each group vs group 1Hazard ratio (95% CI)P value

Group 2

1.70(1.05–2.71)

P < 0.001

Group 3

2.50(1.44–4.30)

P < 0.001

Primary outcome occurred in: 108 (37%) patients

Original publication

A Hemodynamic Echocardiographic Approach to Disease Severity and Prognosis in Transthyretin Amyloid Cardiomyopathy. JACC Adv. Published 22 September 2026. doi:10.1016/j.jacadv.2026.103244

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Summarised from the published abstract; every number is checked against it