Heart failure & cardiomyopathies

A Meta-Analysis of the Relationship Between Glycaemic Variability and the Mortality of Patients with Heart Failure

ESC Heart FailPublished Systematic review and meta-analysis of cohort studies

Pooled result · All-cause mortalityResult — go to the resultRelative risk 2.18 95% CI 1.61–2.96

Authors' conclusion

A high GV could be a risk factor of mortality of patients with HF.

Study context

Population
Patients with heart failure (HF)
Participants
76,843 patients9 cohort studies
Comparison
Higher vs lower glycaemic variability
Outcome
Mortality
Follow-up
Up to 86 months
Methodological detailsrandom-effects model
  • Random-effects model

Pooled result

All-cause mortality

Relative risk

2.18

95% CI 1.61–2.96

P < 0.001

Highervs lower glycaemic variability
RR 2.18 (95% CI 1.61–2.96); P < 0.001

As reported in the abstract

Further pooled results

Mortality by diabetic status, glycaemic variability (GV) type, study design, country, follow-up duration, study quality (subgroups)

Association not significantly influenced by any subgroup factor
P-values for subgroup differences all >0.05

Original publication

A Meta-Analysis of the Relationship Between Glycaemic Variability and the Mortality of Patients with Heart Failure. ESC Heart Fail. Published 19 January 2024. doi:10.1002/ehf2.14627

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