Heart failure & cardiomyopathies

A Multicentre Registry of Hospitalized Patients with Acute and Chronic Heart Failure: Study Design of the H2-Registry

ESC Heart FailPublished prospective, investigator-initiated, multicentre observational registry

Authors' conclusion

The H2-registry is currently the largest ongoing prospective registry of HF patients in Germany. It is foreseeable that the H2-registry will significantly contribute to the collection of real-world data and provide a comprehensive and unique perspective on the current characteristics, treatment strategies, and resulting outcomes of HF patients in Germany. Trial registration number: NCT04844944.

Study context

Population
Inpatients ≥18 years of age with a present diagnosis of chronic or acute heart failure (HF) in secondary and tertiary hospitals throughout Germanyenrolled in 10 study centres until 31 December 2023, 1593 patients with complete follow-up (FU) data for 6- and 12-month outcomes
Participants
2,361 inpatients
Outcome
Baseline characteristics
Methodological detailsinterim analysis
  • Interim analysis

Main finding

As reported in the abstract

Mean age

72 years

Female

36.9%

Median left ventricular ejection fraction

45%

Observational data: associations, not effects.

Further findings

All-cause mortality · 6 and 12 months

All-cause mortality at 6 months
9.0%
All-cause mortality at 12 months
16.2%
  • Cohort of 1593 patients with complete FU data

HF-related rehospitalizations · 6 and 12 months

HF-related rehospitalizations at 6 months
24.4%
HF-related rehospitalizations at 12 months
43.5%
  • Cohort of 1593 patients with complete FU data

Original publication

A Multicentre Registry of Hospitalized Patients with Acute and Chronic Heart Failure: Study Design of the H2-Registry. ESC Heart Fail. Published 13 April 2025. doi:10.1002/ehf2.15266

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