Acute cardiac care & resuscitation
A panel of blood biomarkers unique to sudden cardiac arrest
Authors' conclusion
We identified a panel of novel blood biomarkers specifically associated with SCA, including several that may be involved outside the CAD pathway.
Study context
- Population
- Survivors of sudden cardiac arrest (SCA), blood sampled at a median of 11 months after the eventreplication: 29 cases, 57 controls
- Participants
- 20 / 40 / 20
- Comparison
- SCA survivors vs matched controls
- Casesn = 20
- Controlsn = 40reference
- Coronary artery disease (CAD) controlsn = 20reference
- Outcome
- Protein biomarkers associated with SCA (false discovery rate P<.05)
Methodological detailsage- and sex-matched, replication analysis, Mean age 58 years (range 25-87), 70% male, Mass spectrometry proteomics (data-independent acquisition), cytokine immunoassays, 1153 lipids (13 classes)
- Age- and sex-matched
- Replication analysis
- Mean age 58 years (range 25-87), 70% male
- Mass spectrometry proteomics (data-independent acquisition), cytokine immunoassays, 1153 lipids (13 classes)
Main finding
As reported in the abstract
Protein biomarkers associated with SCA
Protein biomarkers associated with SCA (cases vs controls)
26
Of these, differentiated SCA from CAD
20
Observational data: associations, not effects.
Further findings
Replication analysis
- Biomarkers replicated (of 26)
- 8
- Replicated, not overlapping with CAD
- 6
Biological processes and lipids
- Top processes: extracellular matrix, coagulation cascades, platelet activation
- Lysophosphatidylcholine lipids implicated in SCA through the CAD pathway
Original publication
A panel of blood biomarkers unique to sudden cardiac arrest. Heart Rhythm. Published 13 December 2022. doi:10.
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