A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting
Authors' conclusion
Amongst HCPs and participants who agreed to the trial of genetic data for refinement of clinical risk prediction in primary care, we observed that CVD IRT implementation was feasible and well accepted. The CVD IRT results were associated with planned changes in prevention strategies.
Study context
- Population
- Participants undergoing primary care health checks in the UK NHS
- Participants
- 832 participants12 UK primary care practices
- Comparison
- CVD IRT vs QRISK2
- Outcome
- Feasibility of CVD IRT implementation
Methodological details12 UK primary care practices
- 12 UK primary care practices
Main finding
As reported in the abstract
- CVD IRT scores obtained on blood samples
- 100%
- Healthcare providers (HCPs): CVD IRT could be incorporated into routine primary care straightforwardly
- 90.7%
- Participants 'likely' or 'very likely' to recommend test to family or friends
- 86.9%
- Participants: test personally useful
- 98.8%
- Participants: results easy to understand
- 94.6%
Secondary outcomes
Planned changes in management when CVD IRT exceeded QRISK2
- All participants with CVD IRT > QRISK2
- 108/388 (27.8%)
- Absolute risk score change >2%
- 47% (62/132)
Original publication
A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting. Eur J Prev Cardiol. Published 19 January 2024. doi:10.
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