Arrhythmias & electrophysiology
A Randomized Trial of High vs Standard Power Radiofrequency Ablation for Pulmonary Vein Isolation: SHORT-AF
Authors' conclusion
In patients undergoing AF ablation, HPSD compared with SPSD RFA results in shorter time to achieve PVI, greater freedom from AF at 12 months, and a trend toward increased ACE.
Study context
- Population
- Patients with paroxysmal or persistent (<1 year) atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI)
- Participants
- 60 patients
- Comparison
- High-power, short duration (HPSD) vs standard power, standard duration (SPSD) radiofrequency ablation (RFA) for PVI
- HPSDn = 29
- SPSDn = 31reference
- Primary endpoint
- Time to achieve PVI
Primary result
As reported in the abstract
P = 0.003
Further findings
Left atrial dwell time
P = 0.04
Recurrent atrial arrhythmias · 12 months
HR 0.26 · P = 0.027
First-pass isolation
- No difference between groups in first-pass isolation (79% vs 76%)
- P = 0.65
PV reconnection with adenosine
- No difference between groups in PV reconnection with adenosine (12% vs 20%)
- P = 0.26
Safety
Asymptomatic cerebral emboli (ACE) · trend toward more ACE with HPSD
P = 0.053
Original publication
A Randomized Trial of High vs Standard Power Radiofrequency Ablation for Pulmonary Vein Isolation: SHORT-AF. JACC Clin Electrophysiol. Published 22 February 2023. doi:10.
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