Heart failure & cardiomyopathies

A Scoring Evaluation for the Practical Introduction of Guideline-Directed Medical Therapy in Heart Failure Patients

ESC Heart FailPublished Retrospective cohort study

Authors' conclusion

The developed simple GDMT score was associated with prognosis in HFrEF and HFmrEF patients.

Study context

Population
Patients admitted with HFrEF or heart failure (HF) with mildly reduced EF (HFmrEF), excluding in-hospital death and dialysis
Participants
1,054 patients
Exposure
Simple guideline-directed medical therapy (GDMT) score ≥5 vs <5
Outcome
All-cause death, HF readmission and composite (HF readmission and all-cause death)

Main finding

As reported in the abstract

All-cause death, HF readmission, composite outcome
  • Number of medications not significantly associated with outcomes
  • GDMT score ≥5 vs GDMT score <5: P < 0.001

Observational data: associations, not effects.

Further findings

Almost all subgroups with simple GDMT score ≥5 had a better prognosis

Original publication

A Scoring Evaluation for the Practical Introduction of Guideline-Directed Medical Therapy in Heart Failure Patients. ESC Heart Fail. Published 6 September 2023. doi:10.1002/ehf2.14524

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