Valvular & structural heart disease
Acceleration Time/Ejection Time Ratio Compared to Mean Gradient as a Predictor of Clinical Outcomes Post-TAVR
Authors' conclusion
Post-TAVR AT/ET ≥0.35 can potentially predict clinical outcomes such as HFH.
Study context
- Population
- Patients >18 years undergoing transcatheter aortic valve replacement (TAVR), 2016–2020
- Participants
- 1,900 patients
- Exposure
- Aortic valve (AV) acceleration time (AT)/ejection time (ET) ≥ 0.35 vs AV AT/ET < 0.35 after TAVR
- Outcome
- HF hospitalization and mortality
- Follow-up
- 1 year
Main finding
As reported in the abstract
HF hospitalization
- AT/ET ≥ 0.35 associated with increased 1-year HF hospitalization
- P < 0.001
Observational data: associations, not effects.
Further findings
AT/ET ≥0.35 by valve type
P = 0.001
AV mean gradient >20 vs <20 mm Hg: 1-year HF hospitalization and mortality
- Comparable 1-year HF hospitalization
- P = 0.46
- Comparable mortality
Original publication
Acceleration Time/Ejection Time Ratio Compared to Mean Gradient as a Predictor of Clinical Outcomes Post-TAVR. JACC Cardiovasc Interv. Published 22 September 2025. doi:10.
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