Heart failure & cardiomyopathies
Accelerometry-defined physical activity and quality of life in hypertrophic cardiomyopathy
Authors' conclusion
Objectively measured physical activity was significantly lower in HCM patients compared with G+/P- individuals, particularly among those with symptoms, obstruction or obesity. Even modestly higher daily step counts were associated with better QoL, highlighting the relevance of individualised, phenotype-informed exercise counselling in HCM.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) and genotype-positive, phenotype-negative (G+/P-) individuals
- Participants
- 203 vs 37
- Comparison
- HCM patients compared with G+/P- controls
- HCMn = 203
- G+/P-n = 37
- Outcome
- Daily step counts
Main finding
As reported in the abstract
P < 0.01
Further findings
MVPA (% of the day) · less MVPA in HCM
P < 0.01
Spending >80% of the day sedentary · more often sedentary in HCM
P < 0.01
Activity by HCM subgroup and correlates
- Symptomatic and obstructive HCM patients showed the lowest activity levels
- Asymptomatic obstructive HCM patients demonstrated reduced activity comparable to symptomatic individuals
- Obesity and use of cardiac medications were also associated with lower activity
Step counts and quality of life (QoL)
- Kansas City Cardiomyopathy Questionnaire (KCCQ) score per 250 steps/day increment
- 2.15-point higher
- EQ-5D-5L score per 1000 steps/day increment
- 0.05-point higher
- Both p<0.001
- Remaining significant after adjustment for age and sex
Exercise guidance (HCM patients)
- Recalled receiving exercise guidance
- 62%
- Reported reducing their activity as a result
- 59%
Original publication
Accelerometry-defined physical activity and quality of life in hypertrophic cardiomyopathy. Heart. Published 31 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →