Arrhythmias & electrophysiology
Acquired risk factors and incident atrial fibrillation according to age and genetic predisposition
Authors' conclusion
This study provided comprehensive information about age- and genetic predisposition-related risk factor profiles for AF in a cohort of UK adults.
Study context
- Population
- UK Biobank participants free of atrial fibrillation (AF) at baseline with complete risk factor information (mean age 56 years; 46% men)23,847 developed AF
- Participants
- 409,661 participants
- Exposure
- Risk factor profiles for incident AF across age groups and genetic risk groups
- Outcome
- Incident AF: HRs and PAR% associated with 23 risk factors (social, health behaviours, cardiometabolic, clinical comorbidities, GRS)
- Follow-up
- 5 027 587 person-years of follow-up
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
PAR% of incident AF by risk factor domain, age and genetic risk
| Outcome | 40-49 | 60-69 | Low GRS | High GRS |
|---|---|---|---|---|
| Health behaviours PAR | 11.5% | 8.7% | — not stated in the abstract | — not stated in the abstract |
| Genetic risk factors PAR | 19.1% | 14.3% | — not stated in the abstract | — not stated in the abstract |
| Cardiometabolic factors PAR | — not stated in the abstract | — not stated in the abstract | 41.9% | 34.0% |
| Clinical comorbidities PAR | — not stated in the abstract | — not stated in the abstract | 24.7% | 15.9% |
— not stated in the abstract
- Cardiometabolic factors accounted for the largest number of AF cases across age groups
- Population-attributable risk (PAR): 36.2%-38.9%
- Cardiometabolic factors accounted for the largest number of AF cases across genetic risk groups
- 34.0%-41.9%
- Most cardiometabolic factors and clinical comorbidities interacted with age; associations generally stronger in younger groups
- P for interaction < 0.002
- Only low LDL-C, renal dysfunction and CVD interacted with genetic risk; associations stronger in lower genetic risk groups
- P for interaction < 0.002
Observational data: associations, not effects.
Original publication
Acquired risk factors and incident atrial fibrillation according to age and genetic predisposition. Eur Heart J. Published 19 September 2023. doi:10.
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