Arrhythmias & electrophysiology
Natural history of echocardiographic changes in atrial fibrillation: A case-controlled study of longitudinal remodeling
Authors' conclusion
AF is associated with higher rates of left atrial enlargement, LV systolic and diastolic dysfunction, and mitral regurgitation that typically manifest within 6-24 months of diagnosis.
Study context
- Population
- Patients in the Duke University Health System with ≥2 TTEs, 2005–2018727 matched patients with atrial fibrillation (AF)
- Comparison
- AF vs no AF
- AFn = 727
- Outcome
- Frequency and timing of changes in chamber size, ventricular function, mitral regurgitation, and all-cause mortality
- Follow-up
- 5 years
Methodological detailsmatched on year of TTE, age and CHA2DS2-VASc score, single health system
- Matched on year of TTE, age and CHA2DS2-VASc score
- Single health system
Main finding
As reported in the abstract
AF vs ControlsHazard ratio (95% CI)P value
Left atrial enlargement
1.53(1.27–1.85)
P < 0.001LV systolic dysfunction
1.80(1.00–3.26)
P = 0.045LV diastolic dysfunction
1.51(1.08–2.10)
P = 0.01Moderate or greater mitral regurgitation
2.09(1.27–3.43)
P = 0.003Observational data: associations, not effects.
Original publication
Natural history of echocardiographic changes in atrial fibrillation: A case-controlled study of longitudinal remodeling. Heart Rhythm. Published 16 September 2023. doi:10.
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