Arrhythmias & electrophysiology
Activation signature valleys are predictive of macroreentrant atrial tachycardia bottlenecks where uniform low voltage and uniform slow conduction reside
Authors' conclusion
The AS detects potential bottlenecks for predictive targeting in patients with AT, using differing criteria and often varying locationally from actual targeting, yet identifying areas with similarly uniform low voltage and uniform slow conduction. Predicted targets often coincide with voltage fissures, where sluggish conduction reinforces the excitable gap.
Study context
- Population
- Patients with macroreentrant atrial tachycardiaindex cases, plus 4 repeat ablations (44 procedures)
- Participants
- 40 patients
- Comparison
- Predicted and actual target parameter values were compared for voltage and electrical conduction vs peripheral (nontarget) sites.
- Predicted targetn = 55
- Outcome
- Number of predicted targets per procedure
Main finding
As reported in the abstract
Procedures with 1 predicted target
35
Procedures with 2 targets
7
Procedures with 3 targets
2
Total targets
N = 55
Further findings
Mean voltage
Voltage standard deviation
| Outcome | Peripheral (nontarget) sites | Actual target | Predicted target |
|---|---|---|---|
| Coefficient of variation of the nearest-neighbor activation time difference (lower values indicative of uniform slow conduction) | 1.99 ± 0.46 ms | 1.50 ± 1.08 ms | 0.73 ± 0.23 mV |
- Mean voltage: P < .001
- Voltage standard deviation: P < .001
- Coefficient of variation of the nearest-neighbor activation time difference (lower values indicative of uniform slow conduction): P < .001
- Coefficient of variation of the nearest-neighbor activation time difference (lower values indicative of uniform slow conduction): unit printed as mV for the predicted target and ms for the other sites
Predicted target approximately overlapped the actual target
- Procedures in which a predicted target approximately overlapped the actual target
- 26 of 44
Original publication
Activation signature valleys are predictive of macroreentrant atrial tachycardia bottlenecks where uniform low voltage and uniform slow conduction reside. Heart Rhythm. Published 5 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →