Aortic & peripheral vascular disease
The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture
Authors' conclusion
This cross-sectional compendium of cellular atlas of human ascending aortas during AD progression provides previously unappreciated insights into a transcriptional programme permitting aortic degeneration
Study context
- Population
- Ascending aortas from patients with Stanford type A aortic dissection (AD) undergoing ascending aorta replacement and heart transplantation individuals; β-aminopropionitrile monofumarate-induced AD model93,397 cells
- Comparison
- Coenzyme Q10 or AP-1 inhibitor T-5224 vs no treatment in the AD model
- Outcome
- Survival in the β-aminopropionitrile monofumarate-induced AD model (mice)
Methodological detailssingle-cell RNA sequencing, β-aminopropionitrile monofumarate-induced AD model, Ascending aortas from 9 ascending aorta replacement patients and 5 heart transplantation individuals
- Single-cell RNA sequencing
- β-aminopropionitrile monofumarate-induced AD model
- Ascending aortas from 9 ascending aorta replacement patients and 5 heart transplantation individuals
Main finding
As reported in the abstract
Survival improvement with coenzyme Q10 (58.3%-83.3%)
42.88%
Survival improvement with 2-week T-5224 (33.3%-83.3%)
150.15%
Survival improvement with 3-week T-5224 (33.3%-91.7%)
175.38%
Original publication
The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture. Eur Heart J. Published 22 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it