Heart failure & cardiomyopathies
Added value of semi-quantitative analysis of [18F]FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device
Authors' conclusion
[18F]FDG PET/CT reliably predicts the presence of DRI in LVAD recipients. Semi-quantitative analysis may increase the specificity of [18F]FDG PET/CT for the analysis of central device component infection
Study context
- Population
- LVAD recipients undergoing [18F]FDG PET/CT for suspected device-related infection, 2012–2020
- Participants
- 41 recipients59 episodes
- Comparison
- Visual vs semi-quantitative analysis of [18F]FDG PET/CT
- Outcome
- Diagnostic accuracy for DRI vs final diagnosis (multidisciplinary consensus and surgical findings)
Performance
As reported in the abstract
Driveline infection
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Visual analysis | 0.79 | 0.71 |
| Semi-quantitative analysis | 0.94 | 0.83 |
Sensitivity
Visual analysis0.79
Semi-quantitative analysis0.94
Specificity
Visual analysis0.71
Semi-quantitative analysis0.83
Further findings
| Outcome | Visual analysis | Semi-quantitative analysis | P value |
|---|---|---|---|
| Central device component infection | P = 0.05 | ||
| Sensitivity | 0.75 | 1.0 | |
| Specificity | 0.60 | 0.8 |
- Central device component infection: Central device infection in 6 (11%), combined in 2 (4%) episodes
Original publication
Added value of semi-quantitative analysis of [18F]FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device. Eur Heart J Cardiovasc Imaging. Published 27 December 2022. doi:10.
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