Heart failure & cardiomyopathies
Heart sound–derived systolic time intervals for atrioventricular delay optimization in cardiac resynchronization therapy
Authors' conclusion
AV delays advised by PCG-derived STIs cause only a minimal loss of pump function compared with those based on invasive hemodynamic measurements.
Study context
- Population
- Pigs with atrioventricular (AV) block undergoing biventricular pacing (BiVP) and patients undergoing CRT device implantation5 pigs · 21 patients
- Comparison
- Phonocardiography (PCG)-derived STI-guided AV delay vs invasive haemodynamic-guided AV delay during BiVP
- Outcome
- Error of STI-predicted vs haemodynamically optimal AV delay
Methodological detailsanimal and patient study
- Animal and patient study
Main finding
As reported in the abstract
Error in predicting optimal AV delay
- Pigs: VS1 and S1S2 median error vs optimal AV delay
- 2-28 ms
- Pigs: median loss of pump function
- <2%
- Patients: VS1 error
- 32.5 ms
- Patients: S1S2 error
- 37.5 ms
- Patients: lower left ventricular pressure (LVP) and stroke work
- 0.2%-0.9%
Further findings
Errors in patients with full-capture AV delay >180 ms
ms
- VS1 error
- 21
- S1S2 error
- 24
- 8 patients
Original publication
Heart sound–derived systolic time intervals for atrioventricular delay optimization in cardiac resynchronization therapy. Heart Rhythm. Published 24 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →