Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction
Authors' conclusion
Both adipose tissue n-3 PUFAs fractions and ratios of n-3 PUFAs/AA were associated with a lower occurrence of MI, but ratios provided superior risk prediction.
Study context
- Population
- Random sample of the Diet, Cancer and Health cohort with subcutaneous adipose tissue biopsiescohort n = 57,053
- Participants
- 3,500 participants
- Exposure
- Adipose tissue n-3/n-6 PUFA ratios vs n-3 PUFA fractions as predictors of myocardial infarction (MI)
- Outcome
- Incident MI; predictive power (Harrel's C-index) of n-3 PUFA fractions and n-3/n-6 PUFA ratios
- Follow-up
- 15 years
Methodological detailsrandom subcohort of the Diet, Cancer and Health cohort, Fatty acids determined by gas chromatography
- Random subcohort of the Diet, Cancer and Health cohort
- Fatty acids determined by gas chromatography
Main finding
As reported in the abstract
Incident MI
- Total marine n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA), EPA, EPA/arachidonic acid (AA), DHA/AA and (EPA + docosapentaenoic acid (DPA) + DHA)/AA all inversely associated with risk of incident MI
- Marine n-3 PUFA fractions and EPA/AA, DHA/AA, (EPA + DHA)/AA and (EPA + DPA + DHA)/AA ratios all refined risk prediction over age and sex alone (Harrel's C-index)
- At multivariable analyses, only the ratios provided additional risk prediction
- 2,406 participants experienced an MI during follow-up
Observational data: associations, not effects.
Further findings
Diet and ratios
- Differences in ratios related to differences in food intake
Original publication
Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J. Published 21 April 2023. doi:10.
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