Acute cardiac care & resuscitation
Advanced Lung Cancer Inflammation Index is Associated with Mortality in Critically Ill Patients with Heart Failure
Main finding · All-cause in-hospital mortalityResult — go to the resultHazard ratio 0.97 95% CI 0.94–0.99Authors' conclusion
ALI at baseline can independently predict the risk of short-term mortality in critically ill patients with HF, with lower ALI significantly associated with higher mortality.
Study context
- Population
- Critically ill patients with heart failure (HF) (MIMIC-IV database)
- Participants
- 548 patients
- Exposure
- Lower vs higher ALI
- Outcome
- All-cause in-hospital mortality
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
Hazard ratio
0.97
95% CI 0.94–0.99
P = 0.035
Lowervs higher ALI (per unit, adjusted Cox model)
HR 0.97 (95% CI 0.94–0.99); P = 0.035
- Died in hospital
- 63 (11.5%)
- Higher cumulative incidence with lower ALI (log-rank)
- P < 0.001
- Linear relationship (P for non-linearity)
- 0.211
- ALI added to GWTG-HF: C-statistic improved from 0.62 to 0.68
- P = 0.001
- Continuous net reclassification improvement (NRI) 0.44 (95% CI 0.20, 0.67)
- P < 0.001
- Integrated discrimination improvement (IDI) 0.03 (95% CI 0.01, 0.04)
- P < 0.001
Observational data: associations, not effects.
Secondary outcomes
90-day mortality
| HR (95% CI) | P value | ||
|---|---|---|---|
| ALIAdjusted for confounders | 0.62 (0.39–0.99) | P = 0.046 | |
| 0.20.5125Hazard ratio (log scale) |
- 90-day mortality — Died within 90 days of ICU admission
- 114 (20.8%)
- 90-day mortality — Higher cumulative incidence with lower ALI (log-rank)
- P < 0.001
- 90-day mortality — ALI added to GWTG-HF: C-statistic improved from 0.63 to 0.70
- P < 0.001
- 90-day mortality — Continuous NRI 0.31 (95% CI 0.11, 0.50)
- P = 0.002
- 90-day mortality — IDI 0.01 (95% CI 0.00, 0.02)
- P = 0.034
In-hospital mortality, by sex and age (subgroup)
- Stronger ALI–mortality correlation in males
- interaction P = 0.031
- Stronger ALI–mortality correlation in patients aged over 65 years
- interaction P = 0.010
- C-statistic in patients over 65 years
- 0.66 (95% CI 0.58, 0.74)
Original publication
Advanced Lung Cancer Inflammation Index is Associated with Mortality in Critically Ill Patients with Heart Failure. ESC Heart Fail. Published 2 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →