Aerobic Capacity of Adults With Fontan Palliation: Disease-Specific Reference Values and Relationship to Outcomes
Authors' conclusion
The results of the current study would help calibrate the interpretation of exercise test data in adults with Fontan palliation and improve risk stratification in this population.
Study context
- Population
- Adults with Fontan palliation undergoing cardiopulmonary exercise testing at Mayo Clinic (2003–2023)
- Participants
- 323 adults
- Outcome
- Expected aerobic capacity (predicted peak VO2)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Peak VO2
Median peak VO2 (mL/kg per minute)
19.1
15.2–23.9
Predicted peak VO2 (range 19-88; IQR 41-62)
51%
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Death/transplant per step to next lower predicted peak VO2 quartileNext lower quartilevs Higher quartile47% increase in risk | 1.47 (1.09–2.05) | P = 0.01 | |
| 0.512Adjusted hazard ratio (log scale) |
Multivariable correlates of predicted peak VO2
- BMI: β±SE per 5 kg/m² increase (2.61% decrease), P=0.009
- −2.61±0.95
- Systemic saturation: β±SE per 5% increase (3.65% increase), P<0.001
- 3.65±0.85
- Fontan pressure: β±SE per 1 mm Hg increase (1.24% decrease), P<0.001
- −1.24±0.22
Original publication
Aerobic Capacity of Adults With Fontan Palliation: Disease-Specific Reference Values and Relationship to Outcomes. Circ Heart Fail. Published 9 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →