Age-specific prognosis of acute and steady minor elevations in cardiac troponin among non-acute myocardial infarction inpatients: a large real-world cohort study
Authors' conclusion
In non-AMI inpatients, including older adults, any stable or acute elevation in cTn, even minor, warrants attention. Further studies are needed to assess whether these patients can benefit from more aggressive treatment approaches.
Study context
- Population
- Non-acute myocardial infarction (non-AMI) inpatients with at least two cardiac troponin (cTn) concentrations hospitalised between 2013 and 2022 in the Tianjin Health and Medical Data Platformmean age, 69.6 (13.6) years, 25,037 (43.8%) female
- Participants
- 57,117 participants
- Exposure
- Risk of in-hospital, 30-day and 1-year mortality in different cTn groups
- Outcome
- In-hospital mortality
- Follow-up
- In-hospital
Main finding
As reported in the abstract
Each group vs normal cTnAdjusted hazard ratio (95% CI)
Steady minor elevation
1.70(1.25–2.33)
Acute minor elevation
1.92(1.59–2.32)
Apparent elevation
4.03(3.50–4.65)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality among older adults (subgroup) · 30 days; 30 days to 1 yearAcute minor elevationvs steady minor elevation30-day mortality, older adults | 1.30 (1.02–1.65) | |
| Mortality among older adults (subgroup) · 30 days; 30 days to 1 yearAcute minor elevationvs steady minor elevation30-day to 1-year mortality, older adults | 0.95 (0.82–1.10) | |
| 0.512Hazard ratio (log scale) |
All-cause 30-day and 30-day to 1-year mortality
- Similar trends were found
Short-term and 1-year mortality among non-older adults (subgroup)
- Differences between acute and steady minor elevation groups not statistically significant
- P > 0.05
Original publication
Age-specific prognosis of acute and steady minor elevations in cardiac troponin among non-acute myocardial infarction inpatients: a large real-world cohort study. Heart. Published 16 January 2025. doi:10.
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