Valvular & structural heart disease
Alterations in left atrial and left ventricular coupling in mixed aortic valve disease
Authors' conclusion
Impairments in AV coupling are comparable for patients with MMAVD and those with severe isolated AS or AR. Impairments in LV GLS in MMAVD mirror those found in severe AS.
Study context
- Population
- Patients with moderate mixed aortic valve disease, isolated moderate or severe aortic valve disease, and controls260 patients and 66 controls
- Participants
- 46 / 81 / 50 / 48 / 35 / 66
- Exposure
- Moderate mixed aortic valve disease (MMAVD) vs isolated moderate or severe aortic stenosis (AS) or aortic regurgitation (AR) and controls
- MMAVDn = 46
- Moderate ASn = 81
- Severe ASn = 50
- Moderate ARn = 48
- Severe ARn = 35
- Controlsn = 66reference
- Outcome
- Peak LV and left atrial (LA) longitudinal strain and AV coupling (combined peak LA and LV strain)
Main finding
As reported in the abstract
LV strain
MMAVD
−17.1
mean · SD 1.1 · %
Moderate AS
−17.7
mean · SD 1.5 · %
Severe AS
−17.0
mean · SD 1.5 · %
MMAVD vs Moderate AS: P = 0.02 · MMAVD vs Severe AS: P = 0.74
Observational data: associations, not effects.
Further findings
AV coupling — MMAVD vs Severe AS
P = 0.13
| Outcome | P value |
|---|---|
| AV couplingMMAVD vs Severe AR | P = 0.07 |
Atrioventricular (AV) coupling
- AV coupling significantly lower in MMAVD vs controls and vs moderate AS or AR
Original publication
Alterations in left atrial and left ventricular coupling in mixed aortic valve disease. Eur Heart J Cardiovasc Imaging. Published 9 August 2024. doi:10.
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