Valvular & structural heart diseaseCohort study
Outcomes of moderate mixed aortic valve stenosis and regurgitation
- Multicentre cohort study
- four centres
Authors' conclusion
In moderate MAVD, the presence of symptoms or LVEF < 50% is associated with increased mortality, comparable to isolated severe AS under similar conditions.
Study context
- Population
- Patients with moderate mixed aortic valve disease, isolated severe aortic stenosis (AS) or isolated severe aortic regurgitation (AR)
- Participants
- 1,926 patients · 4 centres
- Exposure
- Moderate mixed aortic valve disease (MAVD) vs isolated severe AS vs isolated severe AR
- Moderate MAVDn = 527
- Severe ASn = 986
- Severe ARn = 413
- Outcome
- All-cause mortality
Main finding
As reported in the abstract
10-year survival (adjusted) · 10 years
P < 0.001
Observational data: associations, not effects.
Further findings
Adjusted mortality by symptoms (subgroup)
- Symptomatic moderate MAVD: mortality comparable to symptomatic severe AS
- Asymptomatic moderate MAVD: mortality similar to severe AR (symptomatic and asymptomatic)
Adjusted mortality by left ventricular ejection fraction (LVEF) (subgroup)
- Moderate MAVD with LVEF < 50%: mortality comparable to severe AS with LVEF < 50%
- Moderate MAVD with LVEF ≥ 50%: mortality similar to severe AR (regardless of LV dysfunction)
Original publication
Outcomes of moderate mixed aortic valve stenosis and regurgitation. Eur Heart J. Published 17 October 2025. doi:10.1093/eurheartj/ehaf791
Summarised from the published abstract; every number is checked against it