Aortic & peripheral vascular disease
Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques
Authors' conclusion
These results highlight a possible key role of cellular metabolism to support inflammation and a high-risk phenotype of atherosclerotic plaques.
Study context
- Population
- Carotid plaques from patients undergoing endarterectomy
- Participants
- 159 carotid plaques
- Comparison
- High-risk vs stable carotid plaques
- Outcome
- Associations between plaque metabolite profiles (165 metabolites), inflammatory mediators and vulnerability
Methodological detailstargeted metabolomics
- Targeted metabolomics
Main finding
As reported in the abstract
- Plaque metabolite profile associated with histological vulnerability, inflammatory mediators and presence of symptoms
- Distinct metabolite profiles in high-risk vs stable plaques, in line with different transcription levels of metabolic enzymes
- High-risk plaques: increased glycolysis, elevated amino acid utilization and decreased fatty acid oxidation
Original publication
Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques. Eur Heart J. Published 19 March 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →