Arrhythmias & electrophysiology
Ambulatory atrioventricular synchronous pacing over time using a leadless ventricular pacemaker: Primary results from the AccelAV study
Authors' conclusion
Accelerometer-based mechanical atrial sensing provided by a leadless pacemaker implanted in the right ventricle significantly improves quality of life in a select cohort of patients with AV block and normal sinus function. AVS remained stable through 3 months, and there were no system upgrades to dual-chamber pacemakers.
Study context
- Population
- Patients implanted with a leadless ventricular pacemaker; primary analysis in complete AV block with normal sinus function54 with complete atrioventricular block (AVB), normal sinus
- Participants
- 152 patients
- Outcome
- Resting AVS in patients with complete AVB and normal sinus function
- Follow-up
- 1 month
Methodological details20 centres
- 20 centres
Main finding
As reported in the abstract
Mean resting atrioventricular synchrony (AVS) at 1 month (normal sinus function, complete AVB, n = 54)
85.4%
Observational data: associations, not effects.
Further findings
Mean ambulatory AVS, normal sinus function and complete AVB · 1 month
- Ambulatory AVS
- 74.8%
Mean ambulatory AVS with programming optimization (subset, n = 20)
- Mean ambulatory AVS with programming optimization
- 82.6%
- Improvement
- 10.5%
- P <.001
QoL (EQ-5D-3L), preimplant to 3 months
- Improved significantly
- P = 0.031
Mean resting AVS at 1 vs 3 months (37 patients with AVB at both)
- Did not differ, 1 vs 3 months
- 86.1% vs 84.1%
- P = .43
Safety
- No upgrades to dual-chamber devices or CRT through 3 months
Original publication
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