Arrhythmias & electrophysiology
Cardioneuroablation for Reflex Syncope: Efficacy and Effects on Autonomic Cardiac Regulation-A Prospective Randomized Trial
Authors' conclusion
This is the first randomized study documenting efficacy of CNA in patients with cardioinhibitory VVS.
Study context
- Population
- Patients with documented symptomatic cardioinhibitory or mixed VVS and positive atropine test
- Participants
- 48 patients
- Comparison
- Cardioneuroablation (CNA) vs optimal nonpharmacologic therapy
- CNAn = 24
- Controln = 24reference
- Primary endpoint
- Time to first syncope recurrence
- Follow-up
- 2-year follow-up
Methodological detailsprospective, open, investigator-initiated
- Prospective
- Open
- Investigator-initiated
Primary result
As reported in the abstract
P = 0.0004
Secondary outcomes
Holter ECG sinus rhythm and heart rate variability (vs baseline)
- After CNA mean sinus rhythm significantly faster and heart rate variability significantly changed toward parasympathetic withdrawal vs baseline
Quality of life (baseline vs end of follow-up)
- CNA: 30 ± 10 vs 10 ± 7 points, significantly improved
- P = 0.0001
- Control: 31 ± 10 vs 30 ± 10 points, stable
- P = 0.5501
Original publication
Cardioneuroablation for Reflex Syncope: Efficacy and Effects on Autonomic Cardiac Regulation-A Prospective Randomized Trial. JACC Clin Electrophysiol. Published 28 August 2022. doi:10.
Summarised from the published abstract; every number is checked against it