American Heart Association cardiovascular health metrics and cancer outcomes: A systematic review and meta-analysis
Authors' conclusion
We provide evidence for a dose response association of better CVH scores with decreased cancer incidence and cancer mortality. Optimizing CVH may improve cancer outcomes.
Study context
- Population
- Cohort studies examining the association of American Heart Association (AHA) cardiovascular health (CVH) metrics with cancer risk and cancer mortalitystudies included in the systematic review
- Participants
- 26 studies
- Comparison
- Low, moderate, and high CVH score groups
- Outcome
- Overall cancer risk
Methodological detailsmeta regression
- Meta regression
Pooled result
As reported in the abstract
Each group vs low (worse)Relative risk (95% CI)P value
Moderate
0.85(0.79–0.91)
P < 0.001High (best)
0.72(0.64–0.81)
P < 0.001- Dose-response coefficient
- −0.09; standard error [SE], 0.02; P < .001
Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| Breast, colorectal and lung cancer riskHigh (best)vs low (worse)Breast | RR 0.72 (95% CI 0.58–0.90) | ||
| Breast, colorectal and lung cancer riskHigh (best)vs low (worse)Colorectal | RR 0.65 (95% CI 0.57–0.74) | ||
| Breast, colorectal and lung cancer riskHigh (best)vs low (worse)Lung | RR 0.34 (95% CI 0.16–0.70) | ||
| Cancer mortalityModeratevs low (worse) | HR 0.64 (95% CI 0.61–0.68) | P < 0.001 | |
| Cancer mortalityHigh (best)vs low (worse) | HR 0.47 (95% CI 0.41–0.53) | P < 0.001 | |
| 0.10.31310Ratio (log scale) |
- Cancer mortality — Meta regression dose-response coefficient, all cancer mortality
- −0.33; SE, 0.05; P < .001
Original publication
American Heart Association cardiovascular health metrics and cancer outcomes: A systematic review and meta-analysis. Am Heart J. Published 18 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →