Acute cardiac care & resuscitation
Amiodarone dose in patients with shockable out-of-hospital cardiac arrest
Main finding · ROSC at ED arrivalResult — go to the resultAdjusted probability difference 6.6% CI 0.9–12.3Authors' conclusion
In patients with shockable OHCA who received 5 or more defibrillation attempts, a dose of amiodarone 300 mg was associated with a similar survival compared with a total dose of amiodarone 450 mg. Further study is needed to evaluate the need for a second administration of amiodarone in patients with shockable OHCA.
Study context
- Population
- Patients with shockable out-of-hospital cardiac arrest (OHCA) who received 5 or more defibrillation attempts and treatment with 300 or 450 mg of amiodarone (2011–2015)
- Participants
- 910 patients
- Exposure
- Amiodarone 300 mg vs amiodarone 450 mg
- Amiodarone 300 mgn = 426
- Amiodarone 450 mgn = 484
- Outcome
- ROSC at ED arrival
Methodological detailsinverse probability weighting, multiple logistic regression model
- Inverse probability weighting
- Multiple logistic regression model
Main finding
As reported in the abstract
Adjusted probability difference
6.6%
CI 0.9–12.3
P = 0.0234
By group
Amiodarone 300 mgvs amiodarone 450 mg
adjusted probability difference 6.6% (CI 0.9–12.3); P = 0.0234
Observational data: associations, not effects.
Further findings
| Outcome | Amiodarone 300 mg | Amiodarone 450 mg | Adjusted probability difference | |
|---|---|---|---|---|
| Survival at hospital dischargeDid not reach statistical significance | 21.3% (95% CI 17.2–25.4) | 18.0% (95% CI 14.6–21.5) | 3.3% (CI −2.3-8.8) | |
| Favorable neurologic outcome at dischargeDid not reach statistical significance | 16.5% (95% CI 12.9–20.2) | 12.7% (95% CI 9.5–16.0) | 3.8% (95% CI −1.2-8.7) | |
| −50510Difference (linear scale) |
Original publication
Amiodarone dose in patients with shockable out-of-hospital cardiac arrest. Resuscitation. Published 11 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →