Coronary disease & ACSRandomised controlled trial
Angiography-Derived Fractional Flow Reserve to Guide Percutaneous Coronary Intervention (PCI)
- Randomised controlled trial
- non-inferiority
- international
Authors' conclusion
Among patients with intermediate coronary-artery lesions undergoing physiological assessment in the cardiac catheterization laboratory, an angiography-guided strategy involving FFRangio was noninferior to a pressure-wire-guided strategy with respect to a composite end point of death, myocardial infarction, or unplanned clinically indicated coronary revascularization at 1 year.
Study context
- Population
- Patients undergoing coronary angiography with at least one intermediate coronary stenosis
- Participants
- 1,930 patients
- Comparison
- FFRangio-guided vs pressure-wire-guided physiological assessment
- FFRangion = 965
- Pressure-wiren = 965reference
- Primary endpoint
- Composite of:
- Death
- MI
- Unplanned
- Clinically indicated coronary revascularization
- Follow-up
- 1 year
Primary result
As reported in the abstract
FFRangio vs Pressure-wireHazard ratio (95% CI)
FFRangio
0.98(0.70–1.39)
Non-inferiority margin 3.5 as printed, not drawn
- upper boundary of 1-sided 97.5% CI 2.1 percentage points
- difference −0.2 percentage points; P for non-inferiority < 0.001
Safety
Bleeding, AKI, procedure-related adverse events
- No apparent differences between the groups
Original publication
Angiography-Derived Fractional Flow Reserve to Guide PCI. N Engl J Med. Published 29 March 2026. doi:10.1056/nejmoa2600949
Summarised from the published abstract; every number is checked against it