Antegrade dissection and re-entry vs retrograde strategy in chronic total occlusion percutaneous coronary intervention: Rationale and design of the ADRENALINE randomized study
Study context
- Population
- Patients with difficult coronary chronic total occlusion (CTO) (J-CTO score ≥2) referred for CTO-PCI in accordance with the hybrid algorithmplanned enrolment, n = 74 randomized
- Participants
- 121 patients
- Planned comparison
- ADR vs retrograde strategy for difficult CTO percutaneous coronary intervention (PCI)
- Primary endpoint
- Total procedure time and successful guidewire crossing (co-primary)
Methodological detailsobservational arm for successful antegrade wiring (AW), 1:1 randomization
- Observational arm for successful AW
- 1:1 randomization
No results yet. This paper sets out the design of a trial; its results are to come.
Further findings
Enrolment status · As of June 14, 2026
- Patients enrolled of the planned 121
- 45
- Randomized
- 26
- Observational
- 19
- The first patient was enrolled on July 29, 2025.
Original publication
Antegrade dissection and re-entry vs retrograde strategy in chronic total occlusion percutaneous coronary intervention: Rationale and design of the ADRENALINE randomized study. Am Heart J. Published 11 July 2026. doi:10.
Summarised from the published abstract; every number is checked against it