Coronary disease & ACSCohort study
Rheumatoid arthritis and risk of myocardial infarction: A nationwide cohort study
- Retrospective cohort study
- matched 1:3
- nationwide
Authors' conclusion
RA was associated with increased MI risk irrespective of seropositivity status.
Study context
- Population
- Adults aged ≥ 40 years newly diagnosed with RA and matched non-RA controls, Korean National Health Insurance System databasematched 1:3
- Participants
- 36,377 vs 109,131
- Exposure
- RA vs non-RA controls
- RAn = 36,377
- Non-RAn = 109,131reference
- Outcome
- MI
- Follow-up
- Mean 5.6 ± 2.3 years
Main finding
As reported in the abstract
Subdistribution hazard ratio
1.84
95% CI 1.67–2.01
Events by group
RA
738
events
Non-RA
1201
events
RA vs Non-RA
sHR 1.84 (95% CI 1.67–2.01)
Observational data: associations, not effects.
Further findings
| Outcome | Values | sHR (95% CI) | |
|---|---|---|---|
| MI by seropositivity — SNRA vs Non-RA | SNRA 186 events · SPRA 552 events | 1.74 (1.49–2.04) | |
| MI by seropositivity — SPRA vs Non-RA | 1.87 (1.69–2.07) | ||
| MI by bDMARD use (exploratory) — bDMARD use vs Non-RA · exploratory analysis | bDMARD use 64 events | 2.34 (2.05–2.67) | |
| MI by bDMARD use (exploratory) — No bDMARD use vs Non-RA · exploratory analysis | 1.81 (1.72–1.91) | ||
| MI by tsDMARD use (exploratory) — tsDMARD use vs Non-RA · not significant · exploratory analysis | tsDMARD use 4 events | 1.43 (0.90–2.28) | |
| MI by tsDMARD use (exploratory) — No tsDMARD use vs Non-RA · exploratory analysis | 1.86 (1.77–1.96) | ||
| 0.20.5125Subdistribution hazard ratio (log scale) |
Original publication
Rheumatoid arthritis and risk of myocardial infarction: A nationwide cohort study. Eur J Prev Cardiol. Published 10 July 2026. doi:10.1093/eurjpc/zwag358
Summarised from the published abstract; every number is checked against it