Antibiotic Prophylaxis and Infective Endocarditis Incidence Following Invasive Dental Procedures: A Systematic Review and Meta-Analysis
Pooled result · Infective endocarditis after invasive dental procedures, individuals at high riskResult — go to the resultPooled relative risk 0.41 95% CI 0.29–0.57Authors' conclusion
While results from time-trend studies were inconsistent, data from case-control/crossover, cohort, and self-controlled case series studies showed that use of antibiotic prophylaxis is associated with reduced risk of infective endocarditis following invasive dental procedures in individuals at high risk, while no association was proven for those at low/unknown risk
Study context
- Population
- Individuals undergoing invasive dental procedures
- Participants
- 1,152,345 individuals30 studies
- Comparison
- Antibiotic prophylaxis vs no antibiotic prophylaxis
- Outcome
- Incidence of infective endocarditis following invasive dental procedures in relation to antibiotic prophylaxis
Methodological detailsrandom-effects meta-analysis, Searched from inception to May 2023; 11 217 records identified, 30 included; all studies of good quality
- Random-effects meta-analysis
- Searched from inception to May 2023; 11 217 records identified, 30 included; all studies of good quality
Pooled result
As reported in the abstract
Infective endocarditis after invasive dental procedures, individuals at high risk
Pooled relative risk
0.41
95% CI 0.29–0.57
Antibiotic prophylaxisvs No antibiotic prophylaxis
pooled RR 0.41 (95% CI 0.29–0.57)
Further pooled results
Infective endocarditis incidence before vs after guideline restriction (time-trend studies)
- Of 19 time-trend studies with formal pre-post analysis: no significant change
- 9
- Significant increase (overall population or subpopulations: high and moderate risk, streptococcus-IE, viridans group streptococci-IE)
- 7
- Significant decrease (overall population and oral streptococcus-IE)
- 3
Original publication
Antibiotic Prophylaxis and Infective Endocarditis Incidence Following Invasive Dental Procedures: A Systematic Review and Meta-Analysis. JAMA Cardiol. Published 1 July 2024. doi:10.
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