Anxiety and Depression Associated With Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors
Authors' conclusion
Anxiety/depression accelerate the development of CVDRFs. This association appears to be most notable among younger women and may be mediated by stress-related neuro-immune pathways.
Study context
- Population
- Mass General Brigham Biobank subjects followed for 10 years (median age 49.6 years; 55.3% female)27,048 (38.0%) developed CVDRFs
- Participants
- 71,214 subjects
- Exposure
- Pre-existing anxiety/depression vs none
- Outcome
- Incident cardiometabolic risk factors (hypertension, hyperlipidemia, DM) and mediation of cardiovascular disease (CVD) risk
- Follow-up
- 10 years
Methodological detailsmediation analysis
- Mediation analysis
Main finding
As reported in the abstract
Incident CVDRF
Anxiety/depression vs No anxiety/depressionOdds ratio (95% CI)P value
Incident CVDRF
1.71(1.59–1.83)
P < 0.001- Time to CVDRF development (shorter)
- β −0.486 (95% CI −0.62 to −0.35); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Log-odds (95% CI) | P value |
|---|---|---|
| Mediation of anxiety/depression–CVD events association by CVDRF developmentIndirect effect via CVDRFs | 0.044 (0.034–0.055) | P < 0.05 |
Neuro-immune pathways and age/sex effects
- Neuro-immune pathways contributed to CVDRF development
- P < 0.05 each
- Younger women had the greatest acceleration in CVDRF development after anxiety/depression
Original publication
Anxiety and Depression Associated With Increased Cardiovascular Disease Risk Through Accelerated Development of Risk Factors. JACC Adv. Published 14 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →