IMPACT-FH Study for Implementing Innovative Family Communication and Cascade Testing Strategies for Familial Hypercholesterolemia
Main finding · Cascade testing uptake (reported completion of genetic or cholesterol testing)Result — go to the resultHigher odds 6.32Authors' conclusion
Strategies implemented improved FH cascade testing uptake compared to previous estimates and in families where no strategy was selected.
Study context
- Population
- Probands with an familial hypercholesterolemia (FH) genetic result from the MyCode Community Health Initiative and their relatives175 probands
- Participants
- 541 / 1,374 / 163
- Comparison
- Adult relatives with ≥1 family communication strategy selected vs without a strategy selected
- At least one strategyn = 541
- Without a strategyn = 1,374reference
- Minor relativesn = 163
- Outcome
- Cascade testing uptake (reported completion of genetic or cholesterol testing)
Main finding
As reported in the abstract
Higher odds
6.32
Events by group
- Selection of direct contact associated with increased cascade testing uptake (higher odds)
- 16.78
Further findings
Strategy selection by probands
- Probands selecting ≥1 strategy for ≥1 adult relative
- 70% (121/175)
- Mean strategies per adult relative
- 1.2
- Relatives per proband
- 11.9
Original publication
IMPACT-FH Study for Implementing Innovative Family Communication and Cascade Testing Strategies for Familial Hypercholesterolemia. JACC Adv. Published 14 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →