Anxiety Disorder and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study
Authors' conclusion
Anxiety disorders were causally associated with greater risk of CHD, MI, and HF but not AF among individuals of European descent.
Study context
- Population
- Individuals of European descent; anxiety genome-wide association study (GWAS) from UK Biobank, CV outcomes from FinnGen16,730 anxiety cases
- Comparison
- Genetically predicted anxiety disorders vs none
- Outcome
- Causal relationship of anxiety disorders with coronary heart disease (CHD), myocardial infarction (MI), heart failure (HF) and atrial fibrillation (AF)
Methodological detailstwo-way analysis
- Two-way analysis
Main finding
As reported in the abstract
Causal association of genetically predicted anxiety disorders with CHD, MI, HF and AF (IVW)
Odds ratio (95% CI)P value
Anxiety disordersCHD
4.496(1.777–11.378)
P = 0.002Anxiety disordersMI
5.042(1.451–17.518)
P = 0.011Anxiety disordersHF
3.255(1.461–7.252)
P = 0.004AFanxiety disordersvs AF: no relationship
1.775(0.612–5.146)
P = 0.29Further findings
Other Mendelian randomization (MR) methods (MR-Egger, weighted median, simple mode, weighted mode)
- Non-significant associations
Reverse causality (two-way analysis)
- No reverse causality
Original publication
Anxiety Disorder and Cardiovascular Disease: A Two-Sample Mendelian Randomization Study. ESC Heart Fail. Published 27 January 2024. doi:10.
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