The association between non-alcoholic liver fatty disease and coronary artery calcification: a two-sample Mendelian randomization study
Pooled result · CACResult — go to the resultBeta 0.01 95% CI −0.02 to 0.03Authors' conclusion
Our two-sample MR analysis did not support that there is a causal association between NAFLD and CAC at genetic level.
Study context
- Population
- European populations, summary-level genome-wide association studies (GWAS) data
- Comparison
- Genetically predicted non-alcohol fatty liver disease (NAFLD) vs coronary artery calcification (CAC)
- Outcome
- Causal association between genetically predicted NAFLD and CAC (IVW)
Methodological detailsrandom-effect meta-analysis, inverse variance weighting (IVW) primary method, weighted median, MR-Egger and MR-PRESSO sensitivity analyses, reverse Mendelian randomization (MR) analysis, validation analysis (liver fat content), positive control (cirrhosis)
- Random-effect meta-analysis
- IVW primary method
- Weighted median, MR-Egger and MR-PRESSO sensitivity analyses
- Reverse MR analysis
- Validation analysis (liver fat content)
- Positive control (cirrhosis)
Pooled result
CAC
Beta
0.01
95% CI −0.02 to 0.03
P = 0.74
As reported in the abstract
Further pooled results
NAFLD (reverse MR, CAC as exposure)
| OR (95% CI) | P value | ||
|---|---|---|---|
| CAC | 1.00 (0.96–1.06) | P = 0.88 | |
| 0.512Odds ratio (log scale) |
CAC (validation analysis, liver fat content)
- No significant association between fatty liver content and CAC
Original publication
The association between non-alcoholic liver fatty disease and coronary artery calcification: a two-sample Mendelian randomization study. Eur J Prev Cardiol. Published 14 October 2024. doi:10.
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