Aortic & peripheral vascular disease
Vascular Phenotypes and Recurrent Arterial Events After Nontraumatic Cervical Artery Dissection
Authors' conclusion
Head-to-pelvis imaging identified frequent extracervical vascular abnormalities in patients with CeAD and phenotypes with distinct recurrent-event patterns. These findings support a cardiovascular arteriopathy framework for CeAD and provide a rationale for prospective studies of phenotype-guided imaging, genetic evaluation, counseling, and surveillance.
Study context
- Population
- Adults with nontraumatic cervical artery dissection evaluated in an institutional vascular medicine clinic
- Participants
- 315 adults
- Comparison
- Isolated CeAD vs FMD-CeAD vs MAAD-CeAD
- Isolated CeADn = 136
- FMD-CeADn = 100reference
- MAAD-CeADn = 79
- Outcome
- Systemic vascular abnormalities
Methodological detailshead-to-pelvis computed tomography and/or magnetic resonance angiography
- Head-to-pelvis computed tomography and/or magnetic resonance angiography
Main finding
As reported in the abstract
Systemic vascular abnormalities (overall)
179 patients
56.8%
Findings below the neck (overall)
125
39.7%
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Recurrent CeADIsolated CeADvs FMD-CeAD | 3.26 (1.43–7.43) | ||
| Incident extracervical artery dissectionMAAD-CeADvs FMD-CeAD | 3.75 (1.17–12.00) | P = 0.026 | |
| 0.050.21520Hazard ratio (log scale) |
- Incident extracervical artery dissection: among patients with FMD-CeAD or MAAD-CeAD; adjusted for age at index CeAD; similar after additional adjustment for baseline aneurysm
Recurrent CeAD
- Recurrent CeAD was most frequent in isolated CeAD
Incident extracervical artery dissection
- Incident extracervical artery dissection occurred most frequently in MAAD-CeAD
Original publication
Vascular Phenotypes and Recurrent Arterial Events After Nontraumatic Cervical Artery Dissection. JACC Adv. Published 5 November 2026. doi:10.
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