Valvular & structural heart disease
Aortic Stenosis Risk in Rheumatoid Arthritis
Authors' conclusion
In this cohort study, RA was associated with a higher risk of developing AS and the subsequent risks of undergoing aortic valve intervention and suffering from AS-related death.
Study context
- Population
- Veterans in Veterans Health Administration (VHA) and Medicare data, 2000–20196,223,150 person-years
- Participants
- 73,070 vs 639,268
- Exposure
- Rheumatoid arthritis (RA) vs no RA
- RAn = 73,070
- No RAn = 639,268reference
- Outcome
- Composite AS:
- Inpatient or outpatient diagnoses
- Surgical or transcatheter aortic valve replacement
- AS-related death
Methodological detailsmatched cohort, Data analysed August 23, 2022, to March 3, 2023
- Matched cohort
- Data analysed August 23, 2022, to March 3, 2023
Main finding
As reported in the abstract
Composite AS
RA
3.97 (95% CI, 3.81-4.13) per 1000 person-years
Incidence rate
No RA
2.45 (95% CI, 2.41-2.49) per 1000 person-years
Incidence rate
Each group vs no RAAdjusted hazard ratio (95% CI)
RA
1.48(1.41–1.55)
- RA
- absolute difference 1.52 per 1000 person-years
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| Aortic valve intervention | 1.34 (1.22–1.48) | |
| AS-related death | 1.26 (1.04–1.54) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Aortic Stenosis Risk in Rheumatoid Arthritis. JAMA Intern Med. Published 31 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →