Valvular & structural heart disease
Worsening tricuspid regurgitation associated with permanent pacemaker and implantable cardioverter-defibrillator implantation: A systematic review and meta-analysis of more than 66,000 subjects
Pooled result · Worsening TRResult — go to the resultOdds ratio 3.18Authors' conclusion
A substantial number of patients undergoing PPM or ICD implantation are at an increased risk of worsening TR.
Study context
- Population
- Patients undergoing permanent pacemaker (PPM) or implantable cardioverter-defibrillator (ICD) implantation
- Participants
- 66,590 patients29 studies
- Comparison
- Device implantation vs no device implantation
- Device implantationn = 1,008
- Controlsn = 58,605reference
- Outcome
- Worsening TR post-device implantation (incidence and predictors)
Methodological detailsElectronic databases searched from inception to January 2023, Log OR used to summarize group differences
- Electronic databases searched from inception to January 2023
- Log OR used to summarize group differences
Pooled result
Worsening TR
Odds ratio
3.18
P < 0.01
As reported in the abstract
- Pooled incidence of ≥1-grade worsening of tricuspid regurgitation (TR) post-device implantation (7777 patients)
- 24%
Further pooled results
| Outcome | Estimate | P value |
|---|---|---|
| Mortality with worsening TR post-device implantation | HR 1.42 | P = 0.02 |
| Predictors of worsening TR post-device implantationLarger right atrial area | OR 1.11 | P < 0.01 |
| Predictors of worsening TR post-device implantationMale vs Female | OR 0.74 | P < 0.01 |
Predictors of worsening TR post-device implantation
- No statistically significant difference by device type (ICD vs PPM)
- RV dysfunction, pulmonary artery pressure, baseline mitral regurgitation, LVEF, baseline AF and age not associated with worsening TR
Original publication
Worsening tricuspid regurgitation associated with permanent pacemaker and implantable cardioverter-defibrillator implantation: A systematic review and meta-analysis of more than 66,000 subjects. Heart Rhythm. Published 26 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →