Valvular & structural heart disease

Percutaneous mitral annuloplasty with the Carillon device: Outcomes in proportionate and disproportionate functional mitral regurgitation

Am Heart JPublished Pooled analysis of 3 trials

Authors' conclusion

Percutaneous mitral annuloplasty with the Carillon device reduces MR in patients with both proportionate and disproportionate FMR, and also results in LV reverse remodeling in those with proportionate FMR.

Study context

Population
Patients with heart failure with reduced ejection fraction (HFrEF) and persistent grade 2+ to 4+ functional mitral regurgitation (FMR), LVEDD >5.5 cm
Participants
74 vs 39
Comparison
Proportionate vs disproportionate FMR treated with Carillon indirect annuloplasty
  • Proportionate FMRn = 74reference
  • Disproportionate FMRn = 39
Outcome
Clinical and echocardiographic outcomes
Follow-up
12 months

Pooled result

As reported in the abstract

No independent relationship between degree of proportionality (continuous) and change in LVEDV

r = 0.17

No independent relationship between degree of proportionality (continuous) and change in LVESV

r = 0.14

Original publication

Percutaneous mitral annuloplasty with the Carillon device: Outcomes in proportionate and disproportionate functional mitral regurgitation. Am Heart J. Published 27 July 2023. doi:10.1016/j.ahj.2023.07.010

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