Valvular & structural heart disease
Comprehensive Myocardial Assessment by Computed Tomography: Impact on Short-Term Outcomes After Transcatheter Aortic Valve Replacement
Authors' conclusion
Comprehensive myocardial quantification of CT-ECV and CT-GLS associated with post-TAVR outcomes in a contemporary low-risk cohort with mostly preserved LVEF.
Study context
- Population
- Patients with symptomatic severe aortic stenosis (AS) undergoing pre-TAVR CT angiography, January 2021 to June 2022
- Participants
- 300 patients
- Exposure
- Computed tomography extracellular volume (CT-ECV) and computed tomography global longitudinal strain (CT-GLS) at pre-TAVR CT angiography vs post-TAVR outcomes
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
median follow-up 16 months (IQR: 12-22 months)
- CT-ECV, multivariable HR (95% CI: 1.02-1.16); P = 0.008
- 1.09
- CT-GLS, multivariable HR (95% CI: 1.01-1.13); P = 0.017
- 1.07
- Elevated CT-ECV and CT-GLS combined (above median for each), HR (95% CI: 2.63-19.36); P < 0.001
- 7.14
- Composite outcomes
- 70
- Deaths
- 38
Observational data: associations, not effects.
Further findings
Baseline myocardial measures
- Median CT-ECV (IQR: 26.2%-32.1%)
- 28.5%
- Median CT-GLS (IQR: −23.8% to −16.3%)
- −20.1%
- Left ventricular ejection fraction (LVEF), mean ± SD 12%
- 58%
Original publication
Comprehensive Myocardial Assessment by Computed Tomography: Impact on Short-Term Outcomes After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Imaging. Published 1 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →