Valvular & structural heart disease
Impact of Epicardial Adipose Tissue on Myocardial Function and Structure in Patients with sEvere Aortic Valve Stenosis
Authors' conclusion
In patients with severe AS, increased EAT volume is independently associated with impaired LA function but not with other features of biventricular morphology, function or tissue composition. The incremental deterioration of LA function, in addition to the afterload imposed by AS in these patients, could increase vulnerability to heart failure and may require consideration as a therapeutic target beyond TAVR.
Study context
- Population
- Patients with severe aortic valve stenosis (AS) undergoing cardiac magnetic resonance imaging (CMR) prior to transcatheter aortic valve replacement (TAVR)median age 80 years, 62% male
- Participants
- One hundred thirty-seven patients
- Exposure
- increased epicardial adipose tissue (EAT) volumes above the median vs lower EAT volumes
Main finding
As reported in the abstract
P = 0.011
Observational data: associations, not effects.
Further findings
Left ventricular (LV) morphology and function; right atrial and ventricular morphology and function; tissue characteristics
- LV morphology and function similar
- all P ≥ 0.216
- Right atrial and ventricular morphology and function similar
- all P ≥ 0.090
- Tissue characteristics similar
- all ≥ 0.229
Left atrial (LA) Es by type of severe AS (subgroup)
- Difference most prominent in patients with low ejection fraction high-gradient AS
Multivariable regression: EAT and LA Es
- EAT independently associated with impaired LA Es, irrespective of co-morbidities, ventricular function, tissue characteristics and functional characteristics of AS
Original publication
Summarised from the published abstract; every number is checked against it