Heart failure & cardiomyopathies
Longitudinal Changes in Left Ventricular Diastolic Function in Late Life: The ARIC Study
Authors' conclusion
Diastolic function generally deteriorates over 6.6 years in late life, particularly among persons with CV risk factors, and is associated with development of dyspnea.
Study context
- Population
- Older adults in the ARIC study with echocardiography at visits 5 (2011–2013) and 7 (2018–2019)
- Participants
- 2,524 adults
- Outcome
- Intraindividual change in diastolic measures: tissue Doppler e', E/e' ratio and LAVI
- Follow-up
- Over 6 years
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
mean 6.6 ± 0.8 years
Change in e'septal (decrease)
0.6 ± 1.4 cm/s
Change in E/e'septal (increase)
3.1 ± 4.4
Change in left atrial volume index (LAVI) (increase)
2.3 ± 6.4 mL/m²
Proportion with ≥2 abnormal diastolic measures, visit 5 to visit 7
17% to 42%
P < 0.001
Observational data: associations, not effects.
Further findings
Change in E/e'septal and LAVI by cardiovascular (CV) risk status
- Greater increases in E/e'septal and LAVI with prevalent CV risk factors or diseases but no prevalent or incident heart failure (HF) (n = 2,150) vs free of CV risk factors or diseases (n = 234)
Dyspnea development between visits
- Increases of E/e'septal and LAVI both associated with development of dyspnea
- Adjusted for CV risk factors
Original publication
Longitudinal Changes in Left Ventricular Diastolic Function in Late Life: The ARIC Study. JACC Cardiovasc Imaging. Published 10 May 2023. doi:10.
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