Arrhythmias & electrophysiology
Arrhythmogenic Right Ventricular Cardiomyopathy With Extensive Abnormal Substrate: Is Isolation Possible?
Authors' conclusion
Electrical isolation of RVFW is feasible and can be the option in ARVC patients with extensive abnormal substrate.
Study context
- Population
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients with ventricular tachycardia (VT) and extensive abnormal right ventricular free wall (RVFW) substrate
- Participants
- 8 consecutive patients
- Outcome
- Feasibility and efficacy of RVFW abnormal substrate isolation to control VT
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- Electrical isolation via endocardial approach alone
- 5 of 8 (62.5%)
- Electrical isolation via combined endocardial and epicardial approach
- 3 of 8 (37.5%)
- Isolation verified by slow automaticity
- 5 of 8, 62.5%
- Isolation verified by RV noncapture
- 3 of 8, 37.5%
- VT inducible before ablation; all patients noninducible after ablation
- 6
- Free of sustained VT during median follow-up of 43 months (range: 24-53 months)
- 7 of 8 (87.5%)
Observational data: associations, not effects.
Further findings
- All patients had RVFW endocardial low-voltage area
- 8
- Entire RV low-voltage area
- 113.8 ± 84.1 cm² (49.6% ± 29.8%)
- Dense scar
- 59.6 ± 39.8 cm² (25.0% ± 14.1%)
Original publication
Arrhythmogenic Right Ventricular Cardiomyopathy With Extensive Abnormal Substrate: Is Isolation Possible? JACC Clin Electrophysiol. Published 18 May 2023. doi:10.
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