Heart failure & cardiomyopathies
Assessing Cardiac Flow Measurements Using a Noninvasive Photoplethysmography-Based Device Compared to Invasive Pulmonary Artery Catheter
Authors' conclusion
The PPG-based device correlates well with invasive methods. (Comparing Cardiac Output Measurements Using a Wearable, Wireless, Non-invasive PPG-Based Device to a Swan Ganz Catheter; NCT04955184).
Study context
- Population
- Heart failure patients undergoing right heart catheterizationincluded in the final analysis, 56.6% [51/90] men, mean age 62 ± 16 years
- Participants
- 90 patients
- Comparison
- Noninvasive wearable PPG-based monitor vs invasive pulmonary artery catheter (thermodilution (TD) and indirect Fick's (IF) methods) for cardiac output (CO) and systemic vascular resistance (SVR)
- Outcome
- Limits of agreement and bias for CO and SVR (Bland-Altman)
Main finding
As reported in the abstract
- PPG vs TD · CO
- bias (limits of agreement −19.1/14.5%) −2.3% (95% CI −4.2/−0.4%)
- PPG vs TD · SVR
- bias (limits of agreement −27.4/12.3%) −7.5% (95% CI −9.7/−5.2%)
- PPG vs IF · CO
- bias (limits of agreement −28.6/29.8%) 0.5% (95% CI −2.7/3.8%)
- PPG vs IF · SVR
- bias (limits of agreement −42.3/20.5%) −10.9% (95% CI −14.4/−7.3%)
- TD vs IF · CO
- bias (limits of agreement −46.1/34.1%) −6.0% (95% CI −10.6/−1.3%)
- TD vs IF · SVR
- bias (limits of agreement −26.8%/58.3%) 15.7% (95% CI 10.7/20.7%)
Further findings
| Outcome | Pearson coefficient (95% CI) |
|---|---|
| Pearson correlation for CO and SVRPPG vs TD · CO | 0.959 (0.938/0.974) |
| Pearson correlation for CO and SVRPPG vs IF · CO | 0.844 (0.767/0.897) |
| Pearson correlation for CO and SVRTD vs IF · CO | 0.775 (0.668/0.851) |
| Pearson correlation for CO and SVRPPG vs TD · SVR | 0.936 (0.902/0.959) |
| Pearson correlation for CO and SVRPPG vs IF · SVR | 0.865 (0.796/0.911) |
| Pearson correlation for CO and SVRTD vs IF · SVR | 0.687 (0.546/0.79) |
Correlations and biases by BMI and skin color tone
- Similar correlations and biases were found with different BMIs and skin color tones
Original publication
Assessing Cardiac Flow Measurements Using a Noninvasive Photoplethysmography-Based Device Compared to Invasive Pulmonary Artery Catheter. JACC Adv. Published 22 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →