Heart failure & cardiomyopathies
Assessing the Link of Malnutrition with Diabetes and Mortality Risk in Heart Failure Patients
Main finding · Association of continuous CONUT with diabetes in HFResult — go to the resultOdds ratio 1.19 95% CI 1.08–1.32Authors' conclusion
Malnutrition assessed by CONUT is linked to higher diabetes prevalence in HF, influenced by altered albumin, cholesterol and lymphocyte levels. CONUT also predicts all-cause and cardiovascular mortality in HF with and without diabetes. Future research should consider dietary assessments and body composition analysis to assess malnutrition in HF patients.
Study context
- Population
- Participants with heart failure (HF) in the National Health and Nutrition Examination Survey (1999–2018)HF participants (median age 70.0 years, 43.8% females), 1500 completed follow-up · with diabetes 586 (39.0%)
- Participants
- 1,501 participants
- Exposure
- Malnutrition (CONUT score and geriatric nutritional risk index (GNRI)) in relation to diabetes and to all-cause and cardiovascular mortality in HF
- HF patients with diabetesn = 586
- Outcome
- Association of continuous CONUT with diabetes in HF
Methodological details1999-2018, propensity score matching, inverse probability weighting, subgroup analyses
- 1999-2018
- Propensity score matching
- Inverse probability weighting
- Subgroup analyses
Main finding
As reported in the abstract
Odds ratio
1.19
95% CI 1.08–1.32
P < 0.001
Observational data: associations, not effects.
Further findings
All-cause and cardiovascular mortality, HF patients with diabetes · follow-up 5.6 [2.8-9.7] years
| HR (95% CI) | P value | ||
|---|---|---|---|
| Continuous CONUTAll-cause mortality | 1.18 (1.09–1.29) | P < 0.001 | |
| Continuous CONUTCardiovascular mortality | 1.26 (1.12–1.42) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
All-cause and cardiovascular mortality, HF patients without diabetes · follow-up 5.6 [2.8-9.7] years
| HR (95% CI) | P value | ||
|---|---|---|---|
| Continuous CONUTAll-cause mortality | 1.12 (1.03–1.22) | P < 0.001 | |
| Continuous CONUTCardiovascular mortality | 1.20 (1.07–1.35) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
- Similar relationships exist for categorized CONUT
Follow-up completeness
- Participants completed follow-up
- 1500
Original publication
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