Heart failure & cardiomyopathies
The Association of Electrical Delay on Hemodynamic Response With Cardiac Resynchronization Therapy
Authors' conclusion
RV-LV and QRS durations are strong predictors of the acute hemodynamic response with CRT. These findings may help in patient selection, lead placement, and pacing benefit expectation.
Study context
- Population
- Patients undergoing cardiac resynchronization therapy (CRT) implantationpatients in 3 prospective studies (PATH-CHF I and II, CRTAVO)
- Participants
- 144 patients
- Comparison
- Electrical delay and acute hemodynamic response to CRT
- Outcome
- Rate of LV pressure rise response
Methodological detailsmulticenter, standardized, randomized stimulation protocol
- Multicenter
- Standardized, randomized stimulation protocol
Pooled result
As reported in the abstract
- The RV-LV interval was associated with an increase in the rate of left ventricular (LV) pressure rise response
Further pooled results
LV effective contractility
- LV effective contractility monotonically increased with a prolongation of the RV-LV time
- Full cohort
Other predictors of increase in rate of LV pressure rise
- QRS duration and, to a lesser extent, female sex and ischemic etiology
Original publication
The Association of Electrical Delay on Hemodynamic Response With Cardiac Resynchronization Therapy. JACC Clin Electrophysiol. Published 12 March 2025. doi:10.
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