Heart failure & cardiomyopathiesCohort study
Impact of Malnutrition in Patients with Severe Heart Failure
- Prospective cohort study
- multicentre
- consecutive patients
Authors' conclusion
In a contemporary, real-world, multicentre cohort of patients with severe HF, malnutrition (defined as GNRI ≤98) was common and independently associated with an increased risk of mortality.
Study context
- Population
- Consecutive patients with severe heart failure (HF) (≥1 high-risk 'I NEED HELP' marker), 4 Italian centres, January 2020–November 2021mean age 74 ± 12 years
- Participants
- 510 patients
- Exposure
- Malnutrition vs no malnutrition
- Malnutritionn = 179
- Outcome
- All-cause mortality
Main finding
All-cause death · 1 year
Adjusted hazard ratio
2.03
95% CI 1.43–2.89
P < 0.001
By group
Malnutrition vs No malnutrition
adjusted HR 2.03 (95% CI 1.43–2.89); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Incidence of malnutrition (geriatric nutritional risk index (GNRI) ≤98)
- 35.1% · 179 of 179
Predictors of malnutrition (multivariable logistic regression)
- Lower body mass index (BMI) independently associated with higher likelihood of malnutrition
- Higher natriuretic peptides (BNP > median 685 pg/ml or NT-proBNP > median 5775 pg/ml) independently associated with higher likelihood of malnutrition
Original publication
Impact of Malnutrition in Patients with Severe Heart Failure. Eur J Heart Fail. Published 29 May 2024. doi:10.1002/ejhf.3285
Summarised from the published abstract; every number is checked against it