Heart failure & cardiomyopathies
Assessment of myocardial injuries in ischaemic and non-ischaemic cardiomyopathies using magnetic resonance T1-rho mapping
Authors' conclusion
Myocardial T1ρ mapping appears to be reproducible and equally sensitive to acute and chronic myocardial injuries, whether of ischaemic or non-ischaemic origins.
Study context
- Population
- Patients with known structural heart disease (ischaemic and non-ischaemic cardiomyopathies) and controls undergoing CMR with T1ρ mapping
- Participants
- 66 vs 44
- Exposure
- Patients with structural heart disease vs controls
- Patientsn = 66
- Controlsn = 44reference
- Outcome
- Clinical correlates of myocardial T1ρ and its change across clinical scenarios
Methodological detailsCMR at 1.5 T
- CMR at 1.5 T
Main finding
As reported in the abstract
Myocardial T1ρ
- T1ρ significantly increased vs controls and remote myocardium in all patient sub-groups and all injury types (acute, chronic, focal, diffuse, ischaemic, non-ischaemic)
- P < 0.05
- In controls, T1ρ positively related with T2
- P = 0.038
- In controls, T1ρ increased from basal to apical levels
- P < 0.001
- T1ρ independently associated with T2 in acute injuries
- P = 0.004
- T1ρ independently associated with native T1 and ECV in chronic injuries
- P < 0.05
Observational data: associations, not effects.
Further findings
Reproducibility of myocardial T1ρ mapping
- Intra-observer intraclass correlation coefficient
- 0.86
- Inter-observer intraclass correlation coefficient
- 0.83
Original publication
Assessment of myocardial injuries in ischaemic and non-ischaemic cardiomyopathies using magnetic resonance T1-rho mapping. Eur Heart J Cardiovasc Imaging. Published 21 November 2023. doi:10.
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