Heart failure & cardiomyopathies
T1 Mapping and Major Cardiovascular Events in Non-Ischaemic Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis
Authors' conclusion
In NIDCM patients, native T1 mapping and ECV were associated with increased risk of the composite primary endpoint of MACE and the secondary endpoint of heart failure and arrhythmic-related events.
Study context
- Population
- Patients with non-ischaemic dilated cardiomyopathy (NIDCM)patients with NIDCM from 12 observational studies
- Participants
- 4,025 patients
- Comparison
- Prognostic role of native T1 mapping and extracellular volume (ECV) in predicting major adverse cardiovascular events (MACE)
- Outcome
- MACE defined as a composite of:
- Heart failure
- Arrhythmic-related events
Methodological details12 observational studies, random effect generic inverse variance
- 12 observational studies
- Random effect generic inverse variance
Pooled result
As reported in the abstract
Pooled hazard ratio (95% CI)
Native T1 mapping valuesI2 31.5%
1.07(1.04–1.09)
ECVI2 0%
1.37(1.29–1.44)
- MACE occurred in
- 610 patients
Further pooled results
HF-related events
| Pooled HR (95% CI) | ||
|---|---|---|
| T1 mappingI2 1% | 1.05 (1.03–1.07) | |
| ECVsI2 63% | 1.43 (1.25–1.61) | |
| 0.512Pooled hazard ratio (log scale) |
Arrhythmic-related events
| Pooled HR (95% CI) | ||
|---|---|---|
| T1 mapping valuesI2 0% | 1.09 (1.07–1.12) | |
| 0.512Pooled hazard ratio (log scale) |
| Outcome | Estimate | |
|---|---|---|
| Native T1 mapping values and ECV, patients with vs without MACEPatients with MACEvs patients without MACEI2 16.72%; higher with a (patients with MACE) | weighted mean difference of native T1 mapping 30.91 (95% CI 18.45–43.16) | |
| Native T1 mapping values and ECV, patients with vs without MACEPatients with MACEvs patients without MACEI2 86%; higher with a (patients with MACE) | mean difference of ECV 4.52 (95% CI 2.78–6.26) | |
| −200204060Difference (linear scale) |
Patients
- HF-related events — HF-related events occurred in
- 492
- Arrhythmic-related events — Arrhythmic-related events occurred in
- 118
Follow-up
- Median follow-up length
- 22 (IQR 14-22) months
Original publication
T1 Mapping and Major Cardiovascular Events in Non-Ischaemic Dilated Cardiomyopathy: A Systematic Review and Meta-Analysis. ESC Heart Fail. Published 25 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →