Cardio-oncology & otherMeta-analysis
Cardiovascular safety of assisted reproductive technology: a meta-analysis
- Systematic review and meta-analysis
- random-effects model
Authors' conclusion
Assisted reproductive technology use does not appear to be significantly associated with an increased long-term risk of cardiovascular diseases in women.
Study context
- Population
- Women; randomised, cohort or case-control studies with adjusted assisted reproductive technology (ART)–CV outcome association, control group and ≥1-year follow-up10 studies
- Participants
- 500,664 vs 36,395,240
- Comparison
- ART vs controls
- ARTn = 500,664
- Controlsn = 36,395,240reference
- Outcome
- Long-term CV risk (MACE, CHD, stroke, VTE, hypertension, DM, HF)
Pooled result
As reported in the abstract
- MACE; I2 87.61%
- Effect size (ES) 1.04 (95% CI 0.88–1.23); P = 0.63
- CHD; I2 24.36%
- ES 0.88 (95% CI 0.71–1.10); P = 0.26
- stroke; I2 70.40%
- ES 1.21 (95% CI 0.92–1.59); P = 0.17
- VTE; I2 49.13%
- ES 0.95 (95% CI 0.70–1.28); P = 0.73
- hypertension; I2 94.63%
- ES 1.08 (95% CI 0.88–1.32); P = 0.46
- DM; I2 78.44%
- ES 1.03 (95% CI 0.86–1.22); P = 0.77
- HF; I2 0.00%
- ES 0.75 (95% CI 0.60–0.94); P = 0.01
Original publication
Cardiovascular safety of assisted reproductive technology: a meta-analysis. Eur Heart J. Published 23 December 2024. doi:10.1093/eurheartj/ehae886
Summarised from the published abstract; every number is checked against it