Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study)
Authors' conclusion
In a population without CVD or diabetes mellitus, impaired microvascular function is associated with cardiovascular risk profiles such as higher SCORE2 risk and CACS.
Study context
- Population
- Swedish adults aged 50–65 years in the SCAPIS cohort, without cardiovascular disease (CVD) or diabetes mellitus
- Participants
- 3,809 adults
- Exposure
- Lowest vs highest quartile of microvascular function
- Outcome
- Association of microvascular function (forearm skin peak blood oxygen saturation, OxyP) with CV risk (SCORE2) and subclinical atherosclerotic burden (CACS, carotid plaques)
Methodological detailspopulation-based, observational
- Population-based
- Observational
Main finding
As reported in the abstract
SCORE2 (10-year risk of fatal and non-fatal CVD events)
Q1 vs Q4Odds ratio (95% CI)
SCORE2 > 10%; adjusted for BMI and high-sensitivity C-reactive protein
4.96(2.76–8.93)
- Mean SCORE2
- relative risk increase 53%
Observational data: associations, not effects.
Further findings
OxyP by subclinical atherosclerotic burden
- OxyP by subclinical atherosclerotic burden — OxyP lower with CACS > 0 and with both carotid plaques and CACS > 0 vs no subclinical atherosclerotic burden
- P < 0.01
Original publication
Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study). Eur J Prev Cardiol. Published 9 February 2024. doi:10.
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